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KMID : 0829220020260040305
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Korean Journal of Oral and Maxillofacial Pathology
2002 Volume.26 No. 4 p.305 ~ p.314
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Involvement of Integrin Signaling in Cobalt Ion-induced Apoptosis
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Abstract
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We studied the cytotoxicity of cobalt ions and molecules involved in the cellular response to cobalt ions in oral squamous carcinoma(OSC) cells. The authors also looked at the change of integrin, which is known as adhesion-related molecule, and integrin-associated proteins. 800(M Co(II) was very effective concentration in inducting cell death of OSC cells and the viability of the cells was significantly hampered after 12 h incubation. We observed DNA fragmentation, the biochemical hallmark of apoptosis, in cells treated with Co(II) for 12 h and 24 h. There was no significant change in the ratio of bax and bcl-2 protein in cells treated with Co(II). The levels of (1 integrin were significantly elevated in cells treated with Co(II) for 24 h. In contrast there was no expression of FAK and paxillin.
The results of the current study emphasize that FAK and integrin interaction may play an important role in cobalt-induced cell apoptosis.
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